Liverpool make two changes to the side that was held 1-1 at Newcastle on 1st October.
Emre Can and Roberto Firmino come in as Daniel Sturridge and the injured Sadio Mane make way.
Mane suffered a hamstring injury while playing for Senegal and is likely to be out for up to six weeks.
Liverpool Team: Mignolet, Gomez, Matip, Lovren, Moreno, Henderson, Can, Wijnaldum, Salah, Coutinho, Firmino.
Subs: Karius, Alexander-Arnold, Klavan, Milner, Oxlade-Chamberlain, Sturridge, Solanke.
Manchester United make three changes to the side that won 4-0 against Crystal Palace on 30 September.
Marcus Rashford and Juan Mata drop to the bench while Marouane Fellaini is injured.
Matteo Darmian, Ander Herrera, and Anthony Martial come into the starting 11.
Manchester United Team: De Gea, Valencia, Smalling, Jones, Darmian, Ander Herrera, Matic, Young, Mkhitaryan, Martial, Lukaku.
Subs: Romero, Lindelof, Mata, Lingard, Rashford, Blind, Tuanzebe.
Liverpool v Manchester United in the Premier League kicks off at Anfield at 12:30 GMT on Saturday 14th October.